解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Muscle insulin sensitivity for stimulating glucose uptake is enhanced in the period after a single bout of exercise. We recently demonstrated that AMPK is necessary for AICAR, contraction, and exercise to enhance muscle and whole-body insulin sensitivity in mice. Correlative observations from both human and rodent ske...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0769
更新日期:2019-09-01 00:00:00
abstract::Exogenous ghrelin reduces glucose-stimulated insulin secretion and endogenous ghrelin protects against hypoglycemia during starvation. Islet ε-cells produce ghrelin and δ-cells express growth hormone secretagogue receptor (GHSR), suggesting the possibility of a paracrine mechanism for islet ghrelin to reach high local...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-0079
更新日期:2019-09-01 00:00:00
abstract::Hyperglycemia-triggered vascular abnormalities are the most serious complications of diabetes mellitus (DM). The major cause of vascular dysfunction in DM is endothelial injury and dysfunction associated with the reduced number and dysfunction of endothelial progenitor cells (EPCs). A major challenge is to identify ke...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-1178
更新日期:2019-08-01 00:00:00
abstract::The kinin B1 receptor (B1R) plays a role in inflammatory and metabolic processes. B1R deletion (B1-/-) protects mice from diet-induced obesity and improves insulin and leptin sensitivity. In contrast, genetic reconstitution of B1R exclusively in adipose tissue reverses the lean phenotype of B1-/- mice. To study the ce...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-1150
更新日期:2019-08-01 00:00:00
abstract::Identifying new causes of permanent neonatal diabetes (PNDM) (diagnosis <6 months) provides important insights into β-cell biology. Patients with Down syndrome (DS) resulting from trisomy 21 are four times more likely to have childhood diabetes with an intermediate HLA association. It is not known whether DS can cause...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-0045
更新日期:2019-07-01 00:00:00
abstract::Fibroblast growth factor 1 (FGF1) has been shown to reverse hyperglycemia in diabetic rodent models through peripheral and central administration routes. Previous studies demonstrated that insulin is required for central and peripheral FGF1 metabolic improvements; however, it is unknown if FGF1 targets insulin secreti...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-1175
更新日期:2019-07-01 00:00:00
abstract::Insulin resistance (IR) is a harbinger of type 2 diabetes (T2D) and partly determined by genetic factors. However, genetically regulated mechanisms of IR remain poorly understood. Using gene expression, genotype, and insulin sensitivity data from the African American Genetics of Metabolism and Expression (AAGMEx) coho...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-1229
更新日期:2019-07-01 00:00:00
abstract::Patient-derived progenitor cell (PC) dysfunction is severely impaired in diabetes, but the molecular triggers that contribute to mechanisms of PC dysfunction are not fully understood. Methylglyoxal (MGO) is one of the highly reactive dicarbonyl species formed during hyperglycemia. We hypothesized that the MGO scavenge...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0933
更新日期:2019-06-01 00:00:00
abstract::Skeletal muscle (SKM) insulin resistance plays a central role in the pathogenesis of type 2 diabetes. Because G-protein-coupled receptors (GPCRs) represent excellent drug targets, we hypothesized that activation of specific functional classes of SKM GPCRs might lead to improved glucose homeostasis in type 2 diabetes. ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0796
更新日期:2019-06-01 00:00:00
abstract::Pancreatic β-cells play a pivotal role in maintaining normoglycemia. Recent studies have revealed that the β-cell is not a homogeneous cell population but, rather, is heterogeneous in a number of properties such as electrical activity, gene expression, and cell surface markers. Identification of specific β-cell subpop...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db19-0072
更新日期:2019-06-01 00:00:00
abstract::Sodium-glucose cotransporter 2 (SGLT2) inhibitors are the most recently approved class of diabetes drugs. Unlike other agents, SGLT2 inhibitors act on the kidney to promote urinary glucose excretion. SGLT2 inhibitors provide multiple benefits, including decreased HbA1c, body weight, and blood pressure. These drugs hav...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/dbi18-0006
更新日期:2019-06-01 00:00:00
abstract::Bariatric surgery has proven to be the most effective treatment for controlling hyperglycemia in severely obese patients with diabetes. We show that fibroblast growth factor 19 (FGF19), a gut hormone, is rapidly induced by bariatric surgery in rodents and humans. Administration of FGF19 achieves diabetes remission ind...
journal_title:Diabetes
pub_type: 杂志文章,随机对照试验
doi:10.2337/db18-1305
更新日期:2019-06-01 00:00:00
abstract::The last two decades have witnessed an explosion of interest in adipocyte biology, coinciding with the upsurge of obesity and metabolic syndrome. Now we have new perspectives on the distinct developmental origins of white, brown, and beige adipocytes and their role in metabolic physiology and disease. Beyond fuel meta...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/dbi18-0009
更新日期:2019-05-01 00:00:00
abstract::Enteroendocrine cells (EECs) produce hormones such as glucagon-like peptide 1 and peptide YY that regulate food absorption, insulin secretion, and appetite. Based on the success of glucagon-like peptide 1-based therapies for type 2 diabetes and obesity, EECs are themselves the focus of drug discovery programs to enhan...
journal_title:Diabetes
pub_type: 评论,杂志文章
doi:10.2337/db18-0883
更新日期:2019-05-01 00:00:00
abstract::Type 1 diabetes studies consistently generate data showing islet β-cell dysfunction and T cell-mediated anti-β-cell-specific autoimmunity. To explore the pathogenesis, we interrogated the β-cell transcriptomes from donors with and without type 1 diabetes using both bulk-sorted and single β-cells. Consistent with immun...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0686
更新日期:2019-05-01 00:00:00
abstract::The molecular underpinnings of β-cell dysfunction and death leading to diabetes are not fully elucidated. The objective of the current study was to investigate the role of endoplasmic reticulum-associated degradation (ERAD) in pancreatic β-cells. Chemically induced ERAD deficiency in the rat insulinoma cell line INS-1...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0624
更新日期:2019-04-01 00:00:00
abstract::Thioredoxin-interacting protein (TXNIP) is an α-arrestin that can bind to and inhibit the antioxidant protein thioredoxin (TXN). TXNIP expression is induced by glucose and promotes β-cell apoptosis in the pancreas, and deletion of its gene in mouse models protects against diabetes. TXNIP is currently studied as a pote...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0557
更新日期:2019-04-01 00:00:00
abstract::Although most patients with type 1 diabetes (T1D) continue to produce small amounts of insulin decades after disease onset, very few β-cells persist within their pancreata. Consequently, the source of persistent insulin secretion within T1D remains unclear. We hypothesized that low-level insulin content within non-β-c...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0305
更新日期:2019-03-01 00:00:00
abstract::Cardiovascular (CV) disease fatality rates are higher for women compared with men with diabetes despite lower rates of obstructive coronary artery disease (CAD). Impaired coronary flow reserve (CFR), the ratio of adenosine-stimulated to rest myocardial blood flow (MBF), is an indicator of coronary microvascular dysfun...
journal_title:Diabetes
pub_type: 杂志文章,随机对照试验
doi:10.2337/db18-0650
更新日期:2019-03-01 00:00:00
abstract::The past decade has witnessed an exponential increase in our ability to search the genome for genetic factors predisposing to cardiovascular disease (CVD) and in particular coronary heart disease (CHD). Identifying these genes could lead to the development of innovative strategies to prevent the cardiovascular complic...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/dbi18-0036
更新日期:2019-03-01 00:00:00
abstract::The sustained expression of the MAFB transcription factor in human islet β-cells represents a distinct difference in mice. Moreover, mRNA expression of closely related and islet β-cell-enriched MAFA does not peak in humans until after 9 years of age. We show that the MAFA protein also is weakly produced within the juv...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0903
更新日期:2019-02-01 00:00:00
abstract::The primary objective of this study was to assess whether the topical administration of two neuroprotective drugs (brimonidine and somatostatin) could prevent or arrest retinal neurodysfunction in patients with type 2 diabetes. For this purpose, adults aged between 45 and 75 years with a diabetes duration ≥5 years and...
journal_title:Diabetes
pub_type: 杂志文章,随机对照试验
doi:10.2337/db18-0682
更新日期:2019-02-01 00:00:00
abstract::The molecular and cellular level reaches of the metabolic dysregulations that characterize diabetes are yet to be fully discovered. As mechanisms underlying management of reactive oxygen species (ROS) gain interest as crucial factors in cell integrity, questions arise about the role of redox cues in the regulation and...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0232
更新日期:2019-01-01 00:00:00
abstract::Progression to clinical type 1 diabetes varies among children who develop β-cell autoantibodies. Differences in autoantibody patterns could relate to disease progression and etiology. Here we modeled complex longitudinal autoantibody profiles by using a novel wavelet-based algorithm. We identified clusters of similar ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0594
更新日期:2019-01-01 00:00:00
abstract::Many common genetic polymorphisms are associated with glycemic traits and type 2 diabetes (T2D), but knowledge about genetic determinants of glycemic traits in pregnancy is limited. We tested genetic variants known to be associated with glycemic traits and T2D in the general population for associations with glycemic t...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0203
更新日期:2018-12-01 00:00:00
abstract::Increased proinsulin secretion, which characterizes type 2 diabetes and insulin resistance, may be due to an intrinsic, primitive defect in proinsulin processing or be secondary to increased demand on β-cells (hyperinsulinemia secondary to insulin resistance). An alternative way to investigate the relation between rel...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0279
更新日期:2018-11-01 00:00:00
abstract::Obesity is usually associated with an increased risk of nonalcoholic fatty liver disease that is characterized by accumulation of excessive triglyceride (TG) in hepatocytes. However, the factors involved in the obesity-induced hepatosteatosis are poorly defined. Here, we report that SRY-box containing gene 4 (Sox4), a...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0184
更新日期:2018-11-01 00:00:00
abstract::Mitochondrial injury is uniformly observed in several murine models as well as in individuals with diabetic kidney disease (DKD). Although emerging evidence has highlighted the role of key transcriptional regulators in mitochondrial biogenesis, little is known about the regulation of mitochondrial cytochrome c oxidase...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-0958
更新日期:2018-11-01 00:00:00
abstract::Childhood obesity and its comorbidities continue to accelerate across the globe. Two-thirds of pregnant women are obese/overweight, as are 20% of preschoolers. Gestational diabetes mellitus (GDM) is escalating, affecting up to 1 in 5 pregnant women. The field of developmental origins of health and disease has begun to...
journal_title:Diabetes
pub_type: 杂志文章,评审
doi:10.2337/dbi17-0011
更新日期:2018-11-01 00:00:00
abstract::The secretion of insulin from β-cells depends on extracellular factors, in particular glucose and other small molecules, some of which act on G-protein-coupled receptors. Fatty acids (FAs) have been discussed as exogenous secretagogues of insulin for decades, especially after the FA receptor GPR40 (G-protein-coupled r...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-1215
更新日期:2018-10-01 00:00:00
abstract::Extracellular ATP (eATP) activates T cells by engaging the P2X7R receptor. We identified two loss-of-function P2X7R mutations that are protective against type 1 diabetes (T1D) and thus hypothesized that eATP/P2X7R signaling may represent an early step in T1D onset. Specifically, we observed that in patients with newly...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-1227
更新日期:2018-10-01 00:00:00
abstract::The changes in β-cell mass (BCM) during the development and progression of diabetes could potentially be measured by radionuclide imaging using radiolabeled exendin. In this study, we investigated the potential of 111In-diethylenetriaminepentaacetic acid-exendin-3 (111In-exendin) in a rat model that closely mimics the...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-1312
更新日期:2018-10-01 00:00:00
abstract::Growth differentiation factor 11 (GDF11) has been shown to promote stem cell activity and rejuvenate the function of multiple organs in old mice, but little is known about the functions of GDF11 in the diabetic rat model of hindlimb ischemia. In this study, we found that systematic replenishment of GDF11 rescues angio...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-1583
更新日期:2018-10-01 00:00:00
abstract::The American Diabetes Association convened a research symposium, "Epigenetics and Epigenomics: Implications for Diabetes and Obesity" on 17-19 November 2017. International experts in genetics, epigenetics, computational biology, and physiology discussed the current state of understanding of the relationships between g...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0537
更新日期:2018-10-01 00:00:00
abstract::The role of interferons, either pathogenic or protective, during autoimmune diabetes remains controversial. Herein, we examine the progression of diabetes in NOD mice lacking the type I (IFNAR) or type II (IFNGR) interferon receptor and, for the first time, in mice deficient in both receptors (double knockout [DKO]). ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db18-0331
更新日期:2018-09-01 00:00:00
abstract::Indoleamine 2,3 dioxygenase-1 (IDO1) is a powerful immunoregulatory enzyme that is deficient in patients with type 1 diabetes (T1D). In this study, we present the first systematic evaluation of IDO1 expression and localization in human pancreatic tissue. Although IDO1 was constitutively expressed in β-cells from donor...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-1281
更新日期:2018-09-01 00:00:00
abstract::Production of reactive oxygen species (ROS) is a key instigator of β-cell dysfunction in diabetes. The pleiotropic cytokine interleukin 6 (IL-6) has previously been linked to β-cell autophagy but has not been studied in the context of β-cell antioxidant response. We used a combination of animal models of diabetes and ...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-1280
更新日期:2018-08-01 00:00:00
abstract::The mechanisms responsible for painful and insensate diabetic neuropathy are not completely understood. Here, we have investigated sensory neuropathy in the Ins2+/Akita mouse, a hereditary model of diabetes. Akita mice become diabetic soon after weaning, and we show that this is accompanied by an impaired mechanical a...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-1306
更新日期:2018-08-01 00:00:00
abstract::Women gain weight and their diabetes risk increases as they transition through menopause; these changes can be partly reversed by hormone therapy. However, the underlying molecular mechanisms mediating these effects are unknown. A novel knock-in mouse line with the selective blockade of the membrane-initiated estrogen...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-1342
更新日期:2018-08-01 00:00:00
abstract::EPHX2 (encoding soluble epoxide hydrolase [sEH]) converts biologically active epoxyeicosatrienoic acids (EETs), anti-inflammatory and profibrinolytic effectors, into the less biologically active metabolites, dihydroxyeicostrienoic acids. We sought to characterize the expression and the function of EPHX2 in diabetic co...
journal_title:Diabetes
pub_type: 杂志文章
doi:10.2337/db17-1336
更新日期:2018-06-01 00:00:00